Title of article :
Diastereoselective synthesis of 1-(tetrahydrofuran-3-yl)-1,3-dihydroisobenzofuran derivatives via Prins bicyclization
Author/Authors :
Reddy، نويسنده , , B.V. Subba and Jalal، نويسنده , , Sayed and Borkar، نويسنده , , Prashant and Yadav، نويسنده , , J.S. and Reddy، نويسنده , , P. Gurava and Sarma، نويسنده , , A.V.S.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
The homoallylic alcohol tethered with a benzylic hydroxyl group, that is, (E)-4-(2-(hydroxymethyl)phenyl)but-3-en-1-ol undergoes smooth Prins bicyclization with various aldehydes in the presence of 20 mol % Sc(OTf)3 and 4 إ MS at 80 °C to afford a novel series of 1-(tetrahydrofuran-3-yl)-1,3-dihydroisobenzofuran derivatives in good yields with high diastereoselectivity.
Keywords :
Prins bicyclization , Lewis acid , 4-(2-(Hydroxymethyl)phenyl)but-3-en-1-olAldehydes , 1-(Tetrahydrofuran-3-yl)-1 , 3-dihydroisobenzofuran
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
