Title of article :
Molecular iodine-mediated S–N and C–N cross-coupling and oxidative aromatization of 3,4-dihydropyrimidin-2(1H)-thiones with secondary amines
Author/Authors :
Quan، نويسنده , , Zheng-Jun and Lv، نويسنده , , Ying and Wang، نويسنده , , Zhongjie and Zhang، نويسنده , , Zhang and Da، نويسنده , , Yuxia and Wang، نويسنده , , Xi-Cun، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
A domino S–N and C–N coupling/oxidative aromatization process to synthesize 2-aminothio-phenylpyrimidines and 2-amino-phenylpyrimidines by S–N and C–N cross-coupling reactions is described. This methodology couples 3,4-dihydropyrimidine-2-thiones and secondary amines catalyzed by molecular iodine. Remarkably the C–N coupled product was obtained via a desulfitative coupling-aromatization reaction in one-pot reaction.
Keywords :
C2-Functionalized pyrimidines , Oxidative aromatization , 3 , 4-Dihydropyrimidin-2(1H)-ones , S–N coupling , C–N coupling
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
