Title of article
2,5-Bis-(sulfonyl)pyrazines as unprecedented building blocks and their SNAr reactions
Author/Authors
Li، نويسنده , , Jie Jack and Meng، نويسنده , , Wei and Wu، نويسنده , , Shung and Wu، نويسنده , , Yong-Jin and Guernon، نويسنده , , Jason and Allen، نويسنده , , Martin P. and Miller، نويسنده , , Michael M. and Cheng، نويسنده , , Peter T. and Chen، نويسنده , , Bang-chi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
5
From page
1938
To page
1942
Abstract
Previously unknown 2,5-bis-sulfonylpyrazines are prepared and their SNAr reactions are investigated. When 2 equiv of thiols are employed, the corresponding bis-thiopyrazines are obtained exclusively. However, phenols or alkoxides gave rise to only the corresponding mono-substituted aryloxy- or alkoxy-sulfonylpyrazines in excellent yields. A carbon nucleophile prepared by treating malonate with NaH also produced the corresponding mono-sulfonylpyrazines. Aliphatic amines and anilines only provided the mono-anilino-sulfonylpyrazines in poor to moderate yields.
Keywords
Pyrazine , SNAr reactions , Bis-(sulfonyl)pyrazines
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884162
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