Author/Authors :
Ding، نويسنده , , Xiaohua and Cui، نويسنده , , Weichen and Li، نويسنده , , Xiang and Ju، نويسنده , , Xuan and Liu، نويسنده , , Dan and Wang، نويسنده , , Shaozhong and Yao، نويسنده , , Zhu-Jun، نويسنده ,
Abstract :
A gram-scale organocatalytic enantioselective Michael addition of α-nitrocyclohexanone to acrolein has been developed, and it was successfully applied to a concise two-step synthesis of (1S)-azaspiro[4.5]decan-6-one, a useful chiral building block for the synthesis of a variety of natural alkaloids.
Keywords :
enantioselective synthesis , Michael addition , Building block , organocatalysis
