Title of article :
Synthesis of 3-benzazepines and azepino[4,5-b]heterocyclic ring systems via intramolecular Friedel–Crafts cyclization
Author/Authors :
Kargbo، نويسنده , , Robert B. and Sajjadi-Hashemi، نويسنده , , Zohreh and Roy، نويسنده , , Sujata and Jin، نويسنده , , Xiaomin and Herr، نويسنده , , R. Jason، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
The intramolecular Friedel–Crafts cyclization was found to be effective for the synthesis of 3-benzazepines and azepino[4,5-b]heterocyclic ring systems using simple allylic bromides tethered to activated aromatic nuclei. Amongst the various Lewis acids screened, Bi(OTf)3 was found to be the most effective ‘ecofriendly’ catalyst for the cyclization.
Keywords :
3-Benzazepines , Friedel–Crafts cyclization , Allylic bromides , Activated aromatic nuclei
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
