Title of article
Spiroaminal model systems of the marineosins with final step pyrrole incorporation
Author/Authors
Panarese، نويسنده , , Joseph D. and Konkol، نويسنده , , Leah C. and Berry، نويسنده , , Cynthia B. and Bates، نويسنده , , Brittney S. and Aldrich، نويسنده , , Leslie N. and Lindsley، نويسنده , , Craig W.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
2231
To page
2234
Abstract
In this Letter, we describe a short, six step enantioselective route to spiroaminal lactam model systems reminiscent of marineosins A and B that has been developed starting from either (R)- or (S)-hydroxysuccinic acid, respectively, in ∼9% overall yield. This route enables late stage incorporation of the pyrrole ring at C5 via nucleophilic displacement of an iminium triflate salt.
Keywords
pyrrole , alkaloid , enantioselective , Marineosin , Iminium triflate
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884294
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