Author/Authors :
McCoy، نويسنده , , Colin P. and Irwin، نويسنده , , Nicola J. and Brady، نويسنده , , Christopher and Jones، نويسنده , , David S. and Andrews، نويسنده , , Gavin P. and Gorman، نويسنده , , Sean P.، نويسنده ,
Abstract :
Herein we report the synthesis, characterisation and hydrolytic release kinetics of a suite of novel, polymerisable ester quinolone conjugates with varying alkenyl chain lengths. Hydrolysis was shown to proceed up to 17-fold faster upon elevation of pH from neutral to pH 9.29, making these conjugates attractive for the development of ‘designer’ infection-resistant urinary biomaterials exploiting the increase in urine pH reported at the onset of catheter-associated infection to trigger drug release.
Keywords :
Chain length , pH elevation , Ester hydrolysis , Drug-polymer conjugates
