Simple approach to the synthesis of 3-fluoro pyrazolo[1,5-a]pyrimidine analogues

A simple method for the synthesis of novel 3-fluoro pyrazolo[1,5-a]pyrimidine analogues has been developed starting from fluoro acetonitrile and benzoyl chloride. The desired compounds are synthesized from a 3-amino-4-fluoro pyrazole intermediate. The versatility of the approach was demonstrated by the synthesis of a small library of pyrazolo[1,5-a]pyrimidine.