Title of article
Iodine(III)-promoted synthesis of oxazolines from N-allylamides
Author/Authors
Moon، نويسنده , , Nicholas G. and Harned، نويسنده , , Andrew M.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
2960
To page
2963
Abstract
PhI(OAc)2 (activated by BF3·OEt2) has been used to promote the oxidative cyclization of N-allylamides to give oxazolines. The reaction products are formed in high yield and, when a branched allylic amine is used, high diastereoselectivity. Initial mechanistic experiments suggest that the final C–O bond is formed from a reactive tight ion pair, rather than a neutral external nucleophile.
Keywords
hypervalent iodine , Oxazolines , diastereoselective reaction , Oxidation , cyclization reaction
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884597
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