Author/Authors :
Yang، نويسنده , , Xiudong and Dong، نويسنده , , Changming and Chen، نويسنده , , Jian and Liu، نويسنده , , Yun-qi and HAN، نويسنده , , Bin and Zhang، نويسنده , , Quan and Chen، نويسنده , , Yue، نويسنده ,
Abstract :
A tubulysin V analogue with triazole/Me modified Tuv fragment was synthesized in 14 linear steps. The triazoltubulysin analogue maintains significant biological activities against several cancer cell lines, and then provides a new insight into the biological conformation of tubulysins.
Keywords :
Synthesis , Triazole , biological activity , Click reaction , Tubulysin
