Author/Authors :
Zhou، نويسنده , , Jian-Qing and Sheng، نويسنده , , Wei-Jian and Jia، نويسنده , , Jianhong and Ye، نويسنده , , Qing and Gao، نويسنده , , Jian-Rong and Jia، نويسنده , , Yi-Xia، نويسنده ,
Abstract :
The enantioselective hydrogenolysis of racemic 3-aryl-3-hydroxyisoindolin-1-ones catalyzed by BINOL-derived chiral phosphoric acid with benzothiazoline as the hydride source is described. The corresponding cyclic diaryl methylamines are obtained in good to excellent yields and up to 91% enantioselectivities.
Keywords :
Chiral phosphoric acid , Hydrogenolysis , Imine reduction , Asymmetric organocatalysis
