Title of article
A novel, two-step synthesis of 4-pyridone-3-carboxamides from 2-cyano-4-pyrones
Author/Authors
Boris I. and Obydennov، نويسنده , , Dmitrii L. and Sidorova، نويسنده , , Ekaterina S. and Usachev، نويسنده , , Boris I. and Sosnovskikh، نويسنده , , Vyacheslav Ya.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
3085
To page
3087
Abstract
Reactions of 2-cyano-6-(trifluoromethyl)-4-pyrone, 2-cyano-4-pyrone, and 2-cyano-6-methyl-4-pyrone with aliphatic and aromatic amines in ethanol at −20 °C for 2–21 days gave 5-amino-3-oxopent-4-enamides in 28–78% yields, which were cyclized with DMF-DMA in toluene under ambient conditions to afford 4-pyridone-3-carboxamides in 31–70% yields.
Keywords
2-Cyano-4-pyrones , 5-Amino-3-oxopent-4-enamides , cyclization , 4-Pyridone-3-carboxamides , DMF-DMA
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884653
Link To Document