Author/Authors :
Bastos، نويسنده , , Dayse dos S. and Silva، نويسنده , , Anna C. and Albert، نويسنده , , André L.M. and Barros، نويسنده , , Wesley M.R. and Slana، نويسنده , , Glaucia B.C.A. and Cardoso، نويسنده , , Jari N. and Lopes، نويسنده , , Rosangela S.C. and Lopes، نويسنده , , Claudio C.، نويسنده ,
Abstract :
The preparation of the alkaloid quindoline (1) from indol (3) through a very direct synthetic approach is described in this work. Several successive heteroaromatic lithiation reaction steps were performed in the same medium producing benzylic alcohol (7) in excellent yield. The alcohol was submitted to catalytic reduction, undergoing concomitant cyclization and aromatization, yielding quindoline (1) in 55% overall yield.
Keywords :
malaria , Quindoline , Heteroaromatic lithiation , Indoloquinolines
