Title of article
An efficient and concise total synthesis of the antimalarial alkaloid quindoline
Author/Authors
Bastos، نويسنده , , Dayse dos S. and Silva، نويسنده , , Anna C. and Albert، نويسنده , , André L.M. and Barros، نويسنده , , Wesley M.R. and Slana، نويسنده , , Glaucia B.C.A. and Cardoso، نويسنده , , Jari N. and Lopes، نويسنده , , Rosangela S.C. and Lopes، نويسنده , , Claudio C.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
3144
To page
3146
Abstract
The preparation of the alkaloid quindoline (1) from indol (3) through a very direct synthetic approach is described in this work. Several successive heteroaromatic lithiation reaction steps were performed in the same medium producing benzylic alcohol (7) in excellent yield. The alcohol was submitted to catalytic reduction, undergoing concomitant cyclization and aromatization, yielding quindoline (1) in 55% overall yield.
Keywords
malaria , Quindoline , Heteroaromatic lithiation , Indoloquinolines
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884676
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