Author/Authors :
Tsatsaroni، نويسنده , , Alexandra and Zoidis، نويسنده , , Grigoris and Zoumpoulakis، نويسنده , , Panagiotis and Tsotinis، نويسنده , , Andrew and Taylor، نويسنده , , Martin C. and Kelly، نويسنده , , John M. and Fytas، نويسنده , , George، نويسنده ,
Abstract :
An explanation for the vast difference observed in the trypanocidal activity between the new secondary (N-methylated) hydroxamic acids 5 and 6, and their primary (nonmethylated) congeners 1a and 2, based on their E/Z conformational behaviour in DMSO, is presented.
Keywords :
E/Z conformational behaviour , Trypanocidal action , Lipophilic hydroxamic acid derivatives , NMR , Molecular modelling studies
