Synthesis of novel heterocyclic acetyl coenzyme-A carboxylase inhibitors via a Claisen rearrangement

The synthesis of functionalized heteroaromatic compounds is of high importance in the discovery of novel herbicides. In this Letter is reported the synthesis of a series of 2-heteroaromatic-1,3-diones utilizing a Claisen rearrangement to form a key carbon–carbon bond. The paper focuses on the scope and diversity of the molecules synthesized via this route.