A solvent-free method for the direct synthesis of Cbz-protected β-amino ketones using triphenylphosphine dibromide

Triphenylphosphine dibromide (TPPDB) has been found to be a very effective catalyst for the one pot three-component Mannich reactions of aryl aldehyde, acetophenone, and benzyl carbamate under solvent-free condition at room temperature. The advantageous features of this methodology are operational simplicity, shorter reaction time, cost-effectiveness, and excellent yields. The catalyst possesses distinct advantages over other catalysts used for this conversion.