Title of article
Diastereoselective synthesis of ring-fused thiocarbamates bearing contiguous quaternary carbon centers
Author/Authors
Guo، نويسنده , , Qi-Xiang and Zhang، نويسنده , , Lijun and Song، نويسنده , , Liu and Xu، نويسنده , , Biao and Xiao، نويسنده , , Dong-Rong and Peng، نويسنده , , Yun-Gui، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
3565
To page
3567
Abstract
An efficient DMAP catalyzed tandem aldol/imidization reaction of α-isothiocyanato esters with α-ketoamides is described, affording ring-fused thiocarbamates bearing contiguous quaternary carbon centers with up to 99% yield in a completely diastereoselective fashion. This method has a wide range of substrate scope and can be used in the synthesis of pyrrolidines.
Keywords
Tandem reaction , aldol reaction , Imidization reaction , DMAP , thiocarbamate
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884855
Link To Document