Author/Authors :
Yu، نويسنده , , Liangliang and Xie، نويسنده , , Xiaohua and Wu، نويسنده , , Song and Wang، نويسنده , , Rongming and He، نويسنده , , Wujun and Qin، نويسنده , , Dabin and Liu، نويسنده , , Quanzhong and Jing، نويسنده , , Linhai، نويسنده ,
Abstract :
An efficient enantioselective Michael addition of 2-naphthols to alkylideneindolenines generated in situ from arenesulfonylalkylindoles has been described. The protocol provides an efficient and convenient access to C-3 alkyl-substituted indole derivatives containing phenolic hydroxyl groups with high yields (up to 96%) and enantioselectivities (up to 98% ee) under mild conditions.
Keywords :
organocatalysis , Michael addition , asymmetric synthesis , Arenesulfonylalkylindole , 2-Naphthol
