Title of article :
A convenient one-pot access to phenanthridinones via Suzuki–Miyaura cross-coupling reaction
Author/Authors :
Tanimoto، نويسنده , , Kouichi and Nakagawa، نويسنده , , Naomichi and Takeda، نويسنده , , Kazutaka and Kirihata، نويسنده , , Mitsunori and Tanimori، نويسنده , , Shinji، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
A convenient one-step access to biologically important phenanthridinones 1 has been realized based upon Suzuki–Miyaura cross-coupling reaction. Reactions of 2-aminophenylboronic acid 2 with 2-halobenzoate 3 took place smoothly to afford substituted phenanthridinones 1 in excellent yields in the presence of palladium(II) acetate and 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (SPhos) as pre-catalysts. A natural product phenaglydon 1b was synthesized in one-pot manner from readily available starting materials in 95% yield.
Keywords :
Phenanthridinone , palladium catalyst , Heterocyclic compounds , Suzuki–Miyaura cross-coupling reaction , one-pot reaction
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
