Title of article :
Biological evaluation of an imidazole-fused 1,3,5-triazepinone nucleoside and its photochemical generation via a 6-azidopurine modified oligonucleotide
Author/Authors :
Komodzi?ski، نويسنده , , Krzysztof and Lepczy?ska، نويسنده , , Jolanta and Ruszkowski، نويسنده , , Piotr and Milecki، نويسنده , , Jan and Skalski، نويسنده , , Bohdan، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
The antitumor effects of a novel imidazole-fused 1,3,5-triazepinone nucleoside on KB, MCF-7, and HeLa cell lines were studied via a sulforhodamine B (SRB) colorimetric assay. The results show that the growth of three cancer cell lines studied was significantly inhibited. A method for incorporation of this novel ‘fat’ nucleoside into oligodeoxynucleotides, based on photochemical transformation of 6-azidopurine has been developed.
Keywords :
6-Azidopurine , Anticancer activity , oligonucleotide , Purine ring expansion photoreaction , 3 , 1 , 5-Triazepinone nucleoside
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
