Neutral bile acid cyclic dimers exhibit fluoride coordination by cooperative aliphatic and triazole CH segments

Neutral cyclic dimers of bile acid incorporating triazole and nonaromatic CH binding segments exhibit unique fluoride coordination properties and the formation of a 1:2 complex is confirmed. Remarkably, the aliphatic CH donors, which are activated and stabilized by the hyperconjugation as well as the electron-withdrawing effect of attached N-triazole and carbonyl groups, can present higher binding affinity than their triazole counterparts.