Convergent synthesis of (+)-xestodecalactone A via a Pd-catalyzed α-arylation reaction

The convergent total synthesis of (+)-xestodecalactone A (1) is reported. In addition, a formal synthesis of (+)-sporostatin has been accomplished by means of intercepting a previously reported intermediate en route to 1. The key reaction utilized was a convergent Pd-catalyzed α-arylation between a boronic acid and an α-bromoester.