Title of article
An efficient preparation of 2-alkyl-oxazoles from 2-iodooxazoles
Author/Authors
Zhang، نويسنده , , Xing and Liu، نويسنده , , Jun and Liu، نويسنده , , Yi and Du، نويسنده , , Yuguo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
4045
To page
4048
Abstract
An efficient synthesis toward 2-alkyl substituted oxazoles has been achieved through Suzuki cross-coupling reaction. Treatment of various alkyl iodides with 9-MeO-BBN, followed by in situ palladium-catalyzed carbon–carbon formation with 2-iodooxazoles obtained the 2-alkyl substituted oxazoles in good to excellent yields. Regioselective C2-alkylation on 2,4-di-iodooxazole under the same reaction conditions was firstly disclosed.
Keywords
2-Alkyl oxazoles , Iodooxazole , regioselective alkylation , Suzuki reaction
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1885057
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