Title of article :
Improved synthesis of N1-substituted orotic acid derivatives
Author/Authors :
Senger، نويسنده , , Nicholas A. and Bowler، نويسنده , , Jeannette T. and Mercado، نويسنده , , Rene S. and Lin، نويسنده , , Sidney and Wu، نويسنده , , Weiming، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
An improved method for the synthesis of N1-substituted orotic acid derivatives is reported. The method involves sequential incorporation of nitrogen atoms to the pyrimidine structure from simple starting materials and thus allows the synthesis of N1-substituted orotic acid derivatives with single 15N label at either N-1 or N-3.
Keywords :
orotic acid , 1-Substituted orotic acid , Orotidine , 1-Substituted uracil , Dihydrouracil , 5-Bromouracil
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
