Title of article
2′-O-{[2,2-dimethyl-2-(2-nitrophenyl) acetyl] oxy} methyl protecting group for RNA synthesis
Author/Authors
Chen، نويسنده , , Ke and Wang، نويسنده , , Wei-Min Qu، نويسنده , , Dezhong and Zhao، نويسنده , , Haoting and Xiong، نويسنده , , Wei and Luo، نويسنده , , Caijie and Yin، نويسنده , , Menghui and Zhang، نويسنده , , Biliang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
4281
To page
4284
Abstract
A new 2′-OH protecting group, {[2,2-dimethyl-2-(2-nitrophenyl)acetyl]oxy} methyl (DAM), has been successfully applied to RNA oligonucleotides synthesis with high coupling efficiency. The 2′-O-DAM method is fully compatible with reagents and conditions employed in automated solid phase synthesis of RNA. Moreover, it can be easily removed via reduction in near-neutral solution.
Keywords
Chemical modification , Solid phase synthesis of RNA , 2?-OH protecting group , siRNA , RNA oligonucleotides
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1885153
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