Title of article
Catalyst controlled regioselective Suzuki cross-coupling of 2-(4-bromophenyl)-5-chloropyrazine
Author/Authors
Ashcroft، نويسنده , , Christopher P. and Fussell، نويسنده , , Steven J. and Wilford، نويسنده , , Katie، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
4529
To page
4532
Abstract
The Suzuki cross-coupling between 2-(4-bromophenyl)-5-chloropyrazine and a range of aryl boronic acids has been investigated. The regioselectivity of the reaction can be switched between the aryl bromide and pyrazinyl chloride positions by changing the ligand associated with the palladium catalyst. Xantphos has shown excellent selectivity for the pyrazinyl chloride, with most other ligands showing preferential selectivity for the aryl bromide.
Keywords
Suzuki , Xantphos , Chemoselectivity , Boronate , Pyrazine
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1885263
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