Organocatalytic enantioselective aza-Friedel–Crafts reaction of sesamols with N-sulfonylimines catalyzed by 6′-OH Cinchona alkaloids

An unprecedented asymmetric aza-Friedel–Crafts reaction of sesamol with N-sulfonylimines has been reported. A variety of N-sulfonylimines reacts with sesamol derivatives in the presence of 6′-OH Cinchona alkaloids to provide a new series of chiral aminophenol adducts in good yield and good to high level of enantioselectivity.