Title of article :
A three-component reaction between 1-substituted-2-methylimidazoles, cyanophenylacetylene, and various aldehydes: stereoselective synthesis of (Z)-(2-cyano-1-phenyl)vinyl ethers of 2-(2-hydroxyalkyl)imidazoles
Author/Authors :
Trofimov، نويسنده , , Boris A. and Andriyankova، نويسنده , , Ludmila V. and Nikitina، نويسنده , , Lina P. and Belyaeva، نويسنده , , Kseniya V. and Mal’kina، نويسنده , , Anastasiya G. and Afonin، نويسنده , , Andrei V. and Ushakov، نويسنده , , Igor’ A.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
A three-component reaction between 1-substituted-2-methylimidazoles (1-Me, Bn), cyanophenylacetylene, and aliphatic (Me, i-Pr, n-Bu) and aromatic (Ph, 4-CN-, 4-O2N-C6H4) aldehydes occurs without a catalyst or solvent at room temperature (20–25 °С) to afford stereoselectively (Z)-(2-cyano-1-phenyl)vinyl ethers of 2-hydroxyalkylimidazoles in 26–57% yields.
Keywords :
Acetylene , Zwitterionic intermediates , imidazoles , Aldehydes , multicomponent reactions
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
