Author/Authors :
Lopes، نويسنده , , Sَnia P. and Menezes، نويسنده , , José C.J.M.D.S. and Hackbarth، نويسنده , , Steffen and Pinto، نويسنده , , Diana C.G.A. and Faustino، نويسنده , , Maria A.F. and Silva، نويسنده , , Artur M.S. and Neves، نويسنده , , Maria G.P.M.S. and Rِder، نويسنده , , Beate and Cavaleiro، نويسنده , , José A.S.، نويسنده ,
Abstract :
New flavonoid–porphyrin conjugates were synthesized using the cross-coupling Buchwald–Hartwig amination for the coupling of flavonoid and porphyrin moieties. A unique di-substituted flavone–porphyrin conjugate was also synthesized under similar reaction conditions for the first time. All the conjugates were fully characterized by NMR spectroscopy. The photophysical properties namely fluorescence and singlet oxygen production were evaluated considering their use for photodynamic therapy applications.
Keywords :
Flavonoids , Porphyrins , Buchwald–Hartwig , photodynamic therapy , singlet oxygen
