Author/Authors :
Boulay، نويسنده , , Alexandre and Laine، نويسنده , , Sophie and Leygue، نويسنده , , Nadine and Benoist، نويسنده , , Eric and Laurent، نويسنده , , Sophie and Vander Elst، نويسنده , , Luce and Muller، نويسنده , , Robert N. and Mestre-Voegtle، نويسنده , , Béatrice and Picard، نويسنده , , Claude، نويسنده ,
Abstract :
In the design of dual-imaging probes, the first functionalized and neutral heterobimetallic Re(I)–Gd(III) complex, highly soluble in aqueous solutions, has been prepared. This system exhibits interesting photophysical properties (λem = 578 nm, ϕ = 1.4%) for optical imaging and substantial higher relaxivity (r1 = 6.6 mM−1 s−1 at 0.47 T and 37 °C) than the clinically used MRI contrast agents. Moreover, this system incorporates an aromatic ester functionality suitable for bioconjugation.
Keywords :
Luminescent agent , MRI agent , Dual imaging probe , Dinuclear complex , Rhenium(I) , Gadolinium(III)
