Author/Authors :
Ren، نويسنده , , Yulin and Jiménez، نويسنده , , Francisco and Garcيa، نويسنده , , Ricardo and Mejيa، نويسنده , , Milciades and Chai، نويسنده , , Heebyung and Farnsworth، نويسنده , , Norman R. and Soejarto، نويسنده , , Djaja D. and Kinghorn، نويسنده , , A. Douglas، نويسنده ,
Abstract :
A new sesquiterpene lactone, rufescenolide C (1), the first furanoheliangolide dimer, was isolated from the leaves of Piptocoma rufescens, collected in the Dominican Republic. Its structure was determined by interpretation of its spectroscopic data, with the absolute configuration being established by analysis of the CD spectrum. A plausible biogenesis of this dimer is proposed. This compound showed potent cytotoxicity with an IC50 value of 150 nM, when tested against HT-29 human colon cancer cells.
