Author/Authors :
Makhluf J. and Ghazvini Zadeh، نويسنده , , Ebrahim H. and Abo-Dya، نويسنده , , Nader E. and Sotuyo، نويسنده , , Ania C. and Ghiviriga، نويسنده , , Ion and Hall، نويسنده , , C. Dennis، نويسنده ,
Abstract :
A convenient method toward the synthesis of α-amino acid-derived unsymmetrical ureas 2 is described herein. This route involves an interesting rearrangement of amides of N-Cbz-α-amino acids 1, which presumably entails the intermediacy of hydantoins that is followed by hydrolysis to afford unsymmetrical ureas 2 in quantitative yields and high purity.
Keywords :
Urea synthesis , Rearrangement , Non-phosgene , ?-Amino acid amides
