Title of article
Microwave-assisted synthesis of N-glycolylneuraminic acid derivatives
Author/Authors
Chopra، نويسنده , , Pradeep and Madge، نويسنده , , Paul D. and Thomson، نويسنده , , Robin J. and Grice، نويسنده , , I. Darren and von Itzstein، نويسنده , , Mark، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
5558
To page
5561
Abstract
A rapid, efficient and scalable synthesis of biologically-relevant N-glycolylneuraminic acid derivatives from the natural N-acetyl (Neu5Ac) precursors has been developed. Microwave irradiation provides accelerated de-N-acetylation compared to more traditional methods, with optimised NaOH-promoted de-N-acetylation in only 15 min. The prepared amines were readily re-N-acylated to afford the corresponding N-glycolyl (Neu5Gc) analogues.
Keywords
8-Polysialic acid , ?-2 , de-N-acetylation , Sialic acid , microwave , N-Glycolylneuraminic
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1885646
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