Title of article :
Total syntheses of proposed (±)-trichodermatides B and C
Author/Authors :
Li، نويسنده , , Qian and Xu، نويسنده , , Yan-Shuang and Ellis، نويسنده , , Gregory A. and Bugni، نويسنده , , Timothy S. and Tang، نويسنده , , Yu and Hsung، نويسنده , , Richard P.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
Total syntheses of putative (±)-trichodermatides B and C are described. These efficient syntheses feature the oxa-[3+3] annulation strategy, leading to B and C along with their respective C2-epimers. However, these synthetic samples are spectroscopically very different from the natural products. DFT calculations of C13 chemical shifts are conducted and the predicted values are in good agreement with those of synthetic samples, thereby questioning the accuracy of structural assignments of trichodermatides B and C.
Keywords :
DFT calculations , Trichodermatides , Biosynthesis , Davis’ oxaziridine , Electrocyclic ring-opening
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
