Improvement of Kidney Apelin and Apelin Receptor in Nitro-L-Arginine-Methyl Ester Induced Rats

Background: We have investigated the effect of 8 weeks aerobic training (AT) and Ferula gummosis supplement (FG) on apelin and apelin receptor (APJ), nitric oxide (NO) and angiotensin converting enzyme (ACE) of hypertensive rats. Materials and Methods: In a experimental study, 50 adult male wistar rats were classified into five groups; 1- AT, 2- FG, 3- combination of aerobic training + Ferula Gummosa supplement (TFG), 4- nitro-L-arginine-methyl ester (L-NAME), 5- shame (control) groups (SH). The rats in the 1 to 4 groups received L-NAME (10 mg/kg, 6 times a week for 8 weeks). Also, the 1 and 3 groups experienced the training of 15 to 22 m/min for 25 to 64 minutes, 5 times a week for 8 weeks, whereas, the 2 and 3 groups received Ferula gummosis supplement (90 mg/kg, 6 times a week for 8 weeks). However, rats in 5 groups received NaCl solution. Results: At protocols resulted in a significant increase in apelin and APJ as compared to control and L-NAME groups. The TFG protocols resulted in a markedly increase in apelin, APJ and significantly decrease of ACE levels as compared to L-NAME group. Chronically administration of L-NAME resulted increased, ACE, and reduced the levels of apelin, APJ and NO, as compared to control group. Conclusion: The results in this study show that physical regular activity with and without herbal treatment induce amplification in apelin/APJ system and down-regulation blood pressure in L-NAME induced hypertension in the rat kidney tissue.