Title of article :
First total synthesis and structure confirmation of diacetylenic polyol (+)-oploxyne B
Author/Authors :
Srihari، نويسنده , , P. and Sathish Reddy، نويسنده , , A. and Yadav، نويسنده , , J.S. and Yedlapudi، نويسنده , , D. and Kalivendi، نويسنده , , Shasi V. Kalivendi، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Pages :
3
From page :
5616
To page :
5618
Abstract :
The first total synthesis of the natural product (+)-oploxyne B is achieved. The synthesis has led to the confirmation of absolute stereochemistry of the natural product. The natural product displayed cytotoxic activity with IC50 values varying from 16 to 53 μM in four cancer cell lines tested.
Keywords :
Cadiot–Chodkiewicz coupling , Bromo acetylene , Ohira–Bestmann , Polyacetylene , acetonide
Journal title :
Tetrahedron Letters
Serial Year :
2013
Journal title :
Tetrahedron Letters
Record number :
1886296
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1886296
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