Title of article
Diethylaminosulfur trifluoride-mediated intramolecular cyclization of 2-hydroxycycloalkylureas to fused bicyclic aminooxazoline compounds and evaluation of their biochemical activity against β-secretase-1 (BACE-1)
Author/Authors
Huestis، نويسنده , , Malcolm P. and Liu، نويسنده , , Wendy and Volgraf، نويسنده , , Matthew and Purkey، نويسنده , , Hans E. and Yu، نويسنده , , Christine and Wang، نويسنده , , Weiru and Smith، نويسنده , , Darin and Vigers، نويسنده , , Guy and Dutcher، نويسنده , , Darrin and Hunt، نويسنده , , Kevin W. and Siu، نويسنده , , Michael، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
6
From page
5802
To page
5807
Abstract
A series of unique bicyclic aminooxazolines were synthesized and found to exhibit micromolar inhibition of β-secretase-1 (BACE-1). The aminooxazolines were procured by an intramolecular diethylaminosulfur trifluoride (DAST)-mediated ring closure of a benzylic urea onto a secondary alcohol.
Keywords
Aminooxazolines , ?-Secretase , Oxazolines , Alzheimer’s Disease , BACE
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1886365
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