Author/Authors :
Liu، نويسنده , , Xinru and Song، نويسنده , , Fuhang and Ma، نويسنده , , Li and Chen، نويسنده , , Caixia and Xiao، نويسنده , , Xue and Ren، نويسنده , , Biao and Liu، نويسنده , , Xueting and Dai، نويسنده , , Huanqin and Piggott، نويسنده , , Andrew M. and Av-Gay، نويسنده , , Yossef and Zhang، نويسنده , , Lixin and Capon، نويسنده , , Robert J.، نويسنده ,
Abstract :
Chemical analysis of an East China Sea marine-derived fungus, Aspergillus sydowii (MF357) returned three new tris-pyrogallol ethers, sydowiols A–C (1–3), and two known bis-pyrogallol ethers, violaceols I (4) and II (5). Structures were assigned on the basis of detailed spectroscopic analysis and by consideration of symmetry. Sydowiols A (1) and C (3) were responsible for the inhibitory activity detected in the crude fungal extract against Mycobacterium tuberculosis protein tyrosine phosphatase A (PtpA).
Keywords :
Mycobacterium tuberculosis , Protein tyrosine phosphatase A (PtpA) , Marine-derived fungus , Aspergillus sydowii
