Title of article :
Benzyne-mediated rearrangement of 3-(2-pyridyl)-1,2,4-triazines into 10-(1H-1,2,3-triazol-1-yl)pyrido[1,2-a]indoles
Author/Authors :
Nikonov، نويسنده , , Igor L. and Kopchuk، نويسنده , , Dmitry S. and Kovalev، نويسنده , , Igor S. and Zyryanov، نويسنده , , Grigory V. and Khasanov، نويسنده , , Albert F. and Slepukhin، نويسنده , , Pavel A. and Rusinov، نويسنده , , Vladimir L. and Chupakhin، نويسنده , , Oleg N.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
The reaction between 5-R-6-R1-3-(2-pyridyl)-1,2,4-triazines and benzyne generated in situ in toluene under reflux results in the formation of 10-(1H-1,2,3-triazol-1-yl)pyrido[1,2-a]indoles 3 in up to 60% yields instead of the expected 3-R-4-R1-1-(2-pyridyl)isoquinolines 2. The crystal structure of product 3c and the proposed mechanism for the formation of 3 are reported.
Keywords :
1 , 2 , Rearrangement , 4-triazines , 1 , 3-Triazoles , 2 , 2-a]indoles , arynes
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
