Author/Authors :
Sedighi، Iraj نويسنده Department of Pediatric,Hamadan University of Medical sciences, Hamadan, Iran. , , Rahimi، Hamid نويسنده Department of Infectious Diseases, Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran Rahimi, Hamid , Emadoleslami، Monir Sadat نويسنده Department of Pediatrics, Isfahan University of Medical Sciences, Isfahan, IR Iran Emadoleslami, Monir Sadat , Fahimzad، Alireza نويسنده Department of Pediatrics, Pediatric Infectious Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran Fahimzad, Alireza , Hosseini، Firuzeh نويسنده Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, IR Iran Hosseini, Firuzeh , Afsharian، Mandana نويسنده , , Akbarzadeh، Ahmad نويسنده Department of Pediatrics, Semnan University of Medical Siences, Semnan, IR Iran Akbarzadeh, Ahmad , Vahedi، Homayon نويسنده Department of Pediatrics, Isfahan University of Medical Sciences, Isfahan, IR Iran Vahedi, Homayon , Amanati، Ali نويسنده Hamadan University of Medical sciences, Hamadan, Iran , , Rezaei، Mansour نويسنده , , Ghadiri، Keyghobad نويسنده ,
Abstract :
Background: Pertussis is a highly communicable, vaccine-preventable respiratory disease; which may circulate even in populations
with high vaccination coverage. Although frequent, but it is often underestimated as a cause of prolonged cough illness in both children
and adults. Without boosting, the protection of the childhood vaccination would be minimal after 10 years. The need for adult booster
vaccination depends on the national epidemiology. Objectives: The aim of this study was to evaluate the seroepidemiological incidence of Pertussis in fresh college students in four majors. Patients and Methods: In a cross sectional multicenter study, blood samples were obtained from 1617 junior students of four universities.
None had received Pertussis booster vaccine in the preceding 10 years. Serum immunoglobulin G (IgG) antibody for Pertussis toxin antigen
was measured. Some social and demographic determinants including age, sex and number of family members were recorded. Results: The mean age of participants was 19.64 ± 2.1 years; positive anti Pertussis toxin IgG levels (by cut point of 94 U/mL) was detected in
31.6%. Positivity rate was associated with sex but not with age or residential area. Conclusions: Pertussis continues to challenge medical and public health professionals. Recent reports of increases in the prevalence and
incidence may be because of the limited time of protection of childhood vaccination. Our study can serve as one of the scarce populationbased
reports from developing countries. A universal cut point should be determined for diagnosis of seropositivity, and a booster of a
cellular vaccine is recommended in adolescence.
