Title of article
α-Aminoamides as ligands in Goldberg amidations
Author/Authors
Mitra، نويسنده , , Aurpon W. and Hansen، نويسنده , , Marvin M. and Laurila، نويسنده , , Michael E. and Kolis، نويسنده , , Stanley P. and Martinelli، نويسنده , , Joseph R.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
6580
To page
6583
Abstract
α-Aminoamides are shown to be useful as ligands in Goldberg amidations. A number of α-aminoamides are examined and the importance of substitution on the α-aminoamides is explored. Acetamide is focused on as the nucleophilic coupling partner due to its low cost, stability and convenience as a protecting group. The initial substrate scope for these catalysts is explored and includes electronically activated and deactivated aryl bromides, however o-substituted aryl bromides are problematic.
Keywords
cross-coupling , Cu catalysis , Aminoamide , Amidation , Acetamide
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1886786
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