Author/Authors :
Tomioka، نويسنده , , Takashi and Takahashi، نويسنده , , Yusuke and Maejima، نويسنده , , Toshihide and Yabe، نويسنده , , Yuki and Iwata، نويسنده , , Hiroki and Hamann، نويسنده , , Mark T.، نويسنده ,
Abstract :
Starting from natural d-mannose, a C(42–63) B-ring tetrahydropyran fragment in karlotoxin 2 has been prepared via a common THP intermediate in a concise manner. E-Selective Julia–Kocienski olefination efficiently assembled a C(51–63) chlorodiene subunit and a C(42–50) tetrahydropyran segment.
Keywords :
Polyketide , Karlotoxin , tetrahydropyran , d-mannose , Julia–Kocienski olefination
