Author/Authors :
Kissane، نويسنده , , Marie G. and Frank، نويسنده , , Scott A. and Rener، نويسنده , , Gregory A. and Ley، نويسنده , , Christopher P. and Alt، نويسنده , , Charles A. and Stroud، نويسنده , , Paul A. and Vaid، نويسنده , , Radhe K. and Boini، نويسنده , , Sathish K. and McKee، نويسنده , , Laura A. and Vicenzi، نويسنده , , Jeffrey T. and Stephenson، نويسنده , , Gregory A.، نويسنده ,
Abstract :
The identification and development of an aldehyde–bisulfite adduct as an isolable starting material in the synthesis of the CETP inhibitor Evacetrapib are described. The physical properties of the sodium and potassium analogs are compared, and the extension of the scope of this study to include an investigation into the solid state properties of a range of sodium and potassium bisulfite adducts of commonly encountered aldehydes is discussed.
Keywords :
Evacetrapib , Solid state properties , Aldehyde–bisulfite adduct , Rosenmund reduction
