• Title of article

    Synthesis of rapamycin glycoconjugates via a CuAAC-based approach

  • Author/Authors

    Moni، نويسنده , , Lisa and Marra، نويسنده , , Alberto and Skotnicki، نويسنده , , Jerauld S. and Koehn، نويسنده , , Frank E. and Abou-Gharbia، نويسنده , , Magid and Dondoni، نويسنده , , Alessandro، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2013
  • Pages
    5
  • From page
    6999
  • To page
    7003
  • Abstract
    The conversion of the C40 secondary hydroxyl group of rapamycin into the azido group was followed by copper catalyzed cycloaddition of the resulting azido-rapamcin with various unprotected propargyl O- and S-glycosides and a C-ethynyl derivative. This approach furnished a collection of triazole-bridged rapamycin glycoconjugates (14 examples) in 44–83% isolated yield.
  • Keywords
    Azido-rapamycin , cycloaddition , Triazole , Sugar alkyne
  • Journal title
    Tetrahedron Letters
  • Serial Year
    2013
  • Journal title
    Tetrahedron Letters
  • Record number

    1886998

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1886998