Title of article
Early introduction of the amino group to the C27–C35 building block of Eribulin
Author/Authors
Rudolph، نويسنده , , Alena and Alberico، نويسنده , , Dino and Jordan، نويسنده , , Robert and Pan، نويسنده , , Ming and Souza، نويسنده , , Fabio E.S. and Gorin، نويسنده , , Boris، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
7059
To page
7061
Abstract
A new synthetic strategy towards the C27–C35 subunit of Eribulin (1) has been devised to include a protected 1,2-amino alcohol at C34–C35. Early introduction of the C35 amino group in the synthesis of 1 increases the efficiency of the route. This new approach can be accomplished on a multi-gram scale and allows for the successful synthesis of Eribulin.
Keywords
Eribulin , Halichondrin B , Ammonolysis , 1 , 2-amino alcohols
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1887020
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