Title of article :
Syntheses of prodelphinidin B1, B2, and B4 and their antitumor activities against human PC-3 prostate cancer cell lines
Author/Authors :
Fujii، نويسنده , , Wataru and Toda، نويسنده , , Kazuya and Matsumoto، نويسنده , , Kiriko and Kawaguchi، نويسنده , , Koichiro and Kawahara، نويسنده , , Sei-ichi and Hattori، نويسنده , , Yasunao and Fujii، نويسنده , , Hiroshi and Makabe، نويسنده , , Hidefumi، نويسنده ,
Abstract :
Total synthesis of prodelphinidin B1, B2, and B4 has been accomplished. The key step is Lewis acid-mediated equimolar condensations between an epigallocatechin and/or a gallocatechin nucleophile and an epigallocatechin and/or a gallocatechin electrophile. The antitumor effects of synthetic prodelphinidin B1–B4 against human PC-3 prostate cancer cell lines have been investigated. These compounds showed significant antitumor effects. Their activity seemed to be little bit stronger than EGCG and prodelphinidin B3, known antitumor agent.
Keywords :
natural product , Anticancer agents , Polyphenols , Synthesis
