Dehydroxylation of stilbenoid oligomers: absolute configuration determination via comparison of experimental and theoretical electronic circular dichroic spectra

Dehydroxylation of naturally occurring oligomeric resveratrol derivatives resulted in the formation of compounds with dramatically reduced principal stable conformers. In addition, dehydroxylation allowed the determination of the absolute configurations of the original resveratrols via comparison of experimental and theoretical electronic circular dichroic spectra. Notably, the absolute configuration of pauciflorol B was identified using this novel procedure, which is the first application of dehydroxylated derivatives for the determination of the absolute configuration of naturally occurring polyphenols.