Title of article
Synthesis of 4-hydroxymethyl-2,4-methanoproline
Author/Authors
Vasiuta، نويسنده , , Roman I. and Gorichko، نويسنده , , Marian V.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
3
From page
466
To page
468
Abstract
The synthesis of 4-hydroxymethyl-2,4-methanoproline, a novel conformationally restricted amino acid, was performed in four steps. This close analogue of naturally occurring amino acids (i.e., proline, hydroxyproline, serine and threonine) was prepared in good overall yield through two intramolecular recyclization reactions of cyclobutane derivatives.
Keywords
cyclizations , amino acids , Steric hindrance , proline , Conformationally rigid
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1887630
Link To Document