Title of article
A novel and effective approach to 4-fluoropyrimidines
Author/Authors
Kseniya N. Sedenkova، نويسنده , , Kseniya N. and Averina، نويسنده , , Elena B. and Grishin، نويسنده , , Yuri K. and Kuznetsova، نويسنده , , Tamara S. and Zefirov، نويسنده , , Nikolay S.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
3
From page
483
To page
485
Abstract
A series of 4-fluoropyrimidine 1-oxides, obtained via three-component heterocyclization, was studied under various reduction conditions. An effective preparative method for the synthesis of 4-fluoropyrimidines from readily available starting materials was elaborated. 4-Fluoro-substituted tetrahydroquinazolines and tetrahydroquinazoline N-oxides were demonstrated to be highly reactive in aromatic nucleophilic substitution.
Keywords
Aromatic nucleophilic substitution , 4-Fluoropyrimidines , Reduction , 4-Fluoropyrimidine N-oxides
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1887650
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