Title of article :
Synthesis of 4-hydroxy-3-[(E)-2-(6-substituted-9H-purin-9-yl)vinyl]coumarins as lipoxygenase inhibitors
Author/Authors :
Theodoros S. and Kallitsakis، نويسنده , , Michael G. and Hadjipavlou-Litina، نويسنده , , Dimitra J. and Peperidou، نويسنده , , Aikaterini and Litinas، نويسنده , , Konstantinos E.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2014
Abstract :
The synthesis of 4-hydroxy-3-[(E)-2-(6-substituted-9H-purin-9-yl)vinyl] coumarins has been achieved from the reactions of 4-hydroxycoumarin with 2-(6-substituted-9H-purin-9-yl)acetaldehydes in DMF under heating. The new compounds showed significant lipoxygenase inhibitory activity (e.g., 6a: IC50 = 6.25 μM).
Keywords :
4-Hydroxycoumarin , modified nucleosides , purines , Lipoxygenase inhibitors
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
